Every time I look at this list I want to change something, and every day of practice and preseason games adds to the pile of data that may or may not be actionable. This will be constantly updated through the end of the preseason, and of course, it should be altered as a draft cheatsheet depending on your league format, scoring, size, and the picks you've previously made. My tiers and rankings will provide additional information to explain the rationale for the rankings. Happy Drafting!
1. Christian McCaffrey, RB, CAR
2. Saquon Barkley, RB, NYG
3. Alvin Kamara, RB, NO
4. Ezekiel Elliott, RB, DAL
5. Travis Kelce, TE, KC
6. David Johnson, RB, ARI
7. DeAndre Hopkins, WR, HOU
8. Davante Adams, WR, GB
9. Julio Jones, WR, ATL
10. Odell Beckham, WR, CLE
11. Nick Chubb, RB, CLE
12. JuJu Smith-Schuster, WR, PIT
13. Mike Evans, WR, TB
14. Tyreek Hill, WR, KC
15. Joe Mixon, RB, CIN
16. James Conner, RB, PIT
17. Michael Thomas, WR, NO
18. T.Y. Hilton, WR, IND
19. LeVeon Bell, RB, NYJ
20. Dalvin Cook, RB, MIN
21. Kerryon Johnson, RB, DET
22. Devonta Freeman, RB, ATL
23. Keenan Allen, WR, LAC
24. Patrick Mahomes II, QB, KC
25. George Kittle, TE, SF
26. Todd Gurley, RB, LAR
27. Melvin Gordon, RB, LAC
28. Julian Edelman, WR, NE
29. Amari Cooper, WR, DAL
30. Adam Thielen, WR, MIN
31. Tyler Lockett, WR, SEA
32. Zach Ertz, TE, PHI
33. Chris Carson, RB, SEA
34. Aaron Jones, RB, GB
35. Leonard Fournette, RB, JAX
36. Josh Jacobs, OAK
37. Brandin Cooks, WR, LAR
38. Stefon Diggs, WR, MIN
39. Allen Robinson, WR, CHI
40. Cooper Kupp, WR, LAR
41. Robert Woods, WR, LAR
42. Sammy Watkins, WR, KC
43. Chris Godwin, WR, TB
44. Antonio Brown, WR, OAK
45. Damien Williams, RB, KC
46. Marlon Mack, RB, IND
47. Christian Kirk, WR, ARI
48. Calvin Ridley, WR, ATL
49. O.J. Howard, TE, TB
50. Derrick Henry, RB, TEN
51. Mark Ingram, RB, BAL
52. Robby Anderson, WR, NYJ
53. Kenny Golladay, WR, DET
54. Corey Davis, WR, TEN
55. Tyler Boyd, WR, CIN
56. Jarvis Landry, WR, CLE
57. A.J. Green, WR, CIN
58. Darrell Henderson, RB, LAR
59. Miles Sanders, RB, PHI
60. Dante Pettis, WR, SF
61. Will Fuller, WR, HOU
62. Sony Michel, RB, NE
63. Deshaun Watson, QB, HOU
64. Evan Engram, TE, NYG
65. James White, RB, NE
66. Mike Williams, WR, LAC
67. D.J. Moore, WR, CAR
68. Curtis Samuel, WR, CAR
69. Alshon Jeffery, WR, PHI
70. Jared Cook, TE, NO
71. Hunter Henry, TE, LAC
72. David Montgomery, RB, CHI
73. Aaron Rodgers, QB, GB
74. Phillip Lindsay, RB, DEN
75. Tevin Coleman, RB, SF
76. Lamar Miller, RB, HOU
77. Larry Fitzgerald, WR, ARI
78. DeSean Jackson, WR, PHI
79. Marvin Jones, WR, DET
80. John Brown, WR, BUF
81. Marquez Valdes-Scantling, WR, GB
82. Kenyan Drake, WR, MIA
83. Keke Coutee, WR, HOU
84. Emmanuel Sanders, WR, DEN
85. Anthony Miller, WR, CHI
86. Kyler Murray, QB, ARI
87. Carson Wentz, QB, PHI
88. Tarik Cohen, RB, CHI
89. Austin Ekeler, RB, LAC
90. Rashaad Penny, RB, SEA
91. Cam Newton, QB, CAR
92. Duke Johnson Jr, RB, HOU
93. Vance McDonald, TE, PIT
94. Matt Ryan, QB, ATL
95. Baker Mayfield, QB, CLE
96. Russell Wilson, QB, SEA
97. Damien Harris, RB, NE
98. Derrius Guice, RB, WAS
99. Justice Hill, RB, BAL
100. D.K. Metcalf, WR, SEA
101. Matt Breida, RB, SF
102. Royce Freeman, RB, DEN
103. Carlos Hyde, RB, KC
104. Jordan Howard, RB, PHI
105. Latavius Murray, RB, NO
106. Courtland Sutton, WR, DEN
107. Devin Funchess WR, IND
108. Dede Westbrook, WR, JAX
109. Andrew Luck, QB, IND
110. David Njoku, TE, CLE
111. Mark Andrews, TE, BAL
112. Dallas Goedert, TE, PHI
113. Lamar Jackson, QB, BAL
114. T.J. Hockenson, DET
115. Mike Davis, RB, CHI
116. Jaylen Samuels, RB, PIT
117. Marquise Goodwin, WR, SF
118. Geronimo Allison, WR, GB
119. LeSean McCoy, RB, BUF
120. Ronald Jones II II, RB, TB
121. Greg Olsen, TE, CAR
122. Justin Jackson, RB, LAC
123. Nyheim Hines, RB, IND
124. Giovani Bernard, RB, CIN
125. Darwin Thompson, RB, KC
126. Devin Singletary, RB, BUF
127. Kareem Hunt, RB, CLE
128. Tony Pollard, RB, DAL
129. Eric Ebron, TE, IND
130. Jack Doyle, TE, IND
131. Miles Boykin, WR, BAL
132. Parris Campbell, WR, IND
133. DeVante Parker, WR, MIA
134. Jared Goff, QB, LAR
135. Dak Prescott, QB, DAL
136. Kenny Stills, WR, MIA
137. Rashard Higgins, WR, CLE
138. Josh Gordon, WR, NE
139. Peyton Barber, RB, TB
140. Malcolm Brown, RB, LAR
141. Jimmy Graham, TE, GB
142. Tyler Eifert, TE, CIN
143. Jameis Winston, QB, TB
144. Mitchell Trubisky, QB, CHI
145. C.J. Anderson, RB, DET
146. Kalen Ballage, RB, MIA
147. Dion Lewis, RB, TEN
148. Chris Thompson, RB, WAS
149. Chase Edmonds, RB, ARI
150. Marquise Brown, WR, BAL
151. John Ross, WR, CIN
152. David Moore, WR, SEA
153. Golden Tate, WR, NYG
154. Mohamed Sanu, WR, ATL
155. Sterling Shepard, WR, NYG
156. Josh Allen, QB, BUF
157. Drew Brees, QB, NO
158. Philip Rivers, QB, LAC
159. Ben Roethlisberger, QB, PIT
160. Michael Gallup, WR, DAL
161. Mecole Hardman, WR, KC
162, Jordan Reed, TE, WAS
163. Delanie Walker, TE, TEN
164. Darren Waller, TE, OAK
165. Trey Quinn, WR, WAS
166. KeeSean Johnson, WR, ARI
167. Tyrell Williams, WR, OAK
168. James Washington, WR, PIT
169. Donte Moncrief, WR, PIT
170. Diontae Johnson, WR, PIT
171. Deebo Samuel, WR, SF
172. Jerick McKinnon, WR, SF
173. Ito Smith, RB, ATL
174. Adrian Peterson, RB, WAS
175. Raheem Mostert, WR, SF
176. Benny Snell, RB, PIT
177. Alexander Mattison, RB, MIN
178. Dexter Williams, RB, GB
179. Jordan Wilkins, RB, IND
180. Jamaal Williams, RB, GB
181. Brian Hill, RB, ATL
182. Ryquell Armstead, RB, JAX
183. Quincy Enunwa, WR, NYJ
184. Jamison Crowder, WR, NYJ
185. Nelson Agholor, WR, PHI
186. Preston Williams, WR, MIA
187. Jake Kumerow, WR, GB
188. Andy Isabella, WR, ARI
189. NKeal Harry, WR, NE
190. Hakeem Butler, WR, ARI
191. Jimmy Garoppolo, QB, SF
192. Kirk Cousins, QB, MIN
193. Tom Brady, QB, NE
194. Chris Conley, WR, JAX
195. Maurice Harris, WR, NE
196. Jalen Richard, RB, OAK
197. Theo Riddick, RB, DEN
198. Rex Burkhead, RB, NE
199. Dontrell Hilliard, RB, CLE
200. Phillip Dorsett, WR, NE
201. D.J. Chark, WR, JAX
202. Austin Hooper, TE, ATL
203. Jason Witten, TE, DAL
204. Paul Richardson Jr, WR, WAS
205. Taylor Gabriel, WR, CHI
206. Travis Benjamin, WR, LAC
207. Ted Ginn Jr, WR, NO
208. Demaryius Thomas, WR, NE
209. TreQuan Smith, WR, NO
210. Jordan Thomas, TE, HOU
211. Zay Jones, WR, BUF
212. Antonio Callaway, WR, CLE
213. Demarcus Robinson, WR, KC
214. Robert Foster, WR, BUF
215. Breshad Perriman, WR, TB
216. Scott Miller, WR, TB
217. Josh Malone, WR, CIN
218. J.J. Arcega-Whiteside, WR, PHI
219. A.J. Brown, WR, TEN
220. Josh Reynolds, WR, LAR
221. Willie Snead, WR, BAL
222. Danny Amendola, WR, DET
223. Cole Beasley, WR, BUF
224. Randall Cobb, WR, DAL
225. Adam Humphries, WR, TEN
226. Hunter Renfrow, WR, OAK
227. Kenneth Dixon, RB, BAL
228. Ty Montgomery, RB, NYJ
229. Gus Edwards, RB, BAL
230. Marcus Mariota, QB, TEN
231. Andy Dalton, QB, CIN
232. Matthew Stafford, QB, DET
233. Equanimeous St. Brown, WR, GB
234. Deon Cain, WR, IND
235. Terry McLaurin, WR, WAS
236. Trent Sherfield, WR, ARI
237. Sam Darnold, QB, NYJ
238. Derek Carr, QB, OAK
239. Trent Taylor, WR, SF
240. Albert Wilson, WR, MIA
241. DaeSean Hamilton, WR, DEN
242. Kyle Rudolph, TE, MIN
243. Trey Burton, TE, CHI
244. Chris Herndon, TE, NYJ
245. Ben Watson, TE, NE
246. Noah Fant, TE, DEN
247. Byron Pringle, WR, KC
248. Josh Doctson, WR, WAS
249. Jaron Brown, WR, SEA
250. Cordarrelle Patterson, WR, CHI