Favorite Games
- Detroit Lions at Minnesota Vikings - Over/Under 52.5
- Los Angeles Rams at Arizona Cardinals - Over/Under 48.5
- Buffalo Bills at Miami Dolphins - Over/Under 52.5
- Baltimore Ravens at New England Patriots - Over/Under 43.5
- Green Bay Packers at Tampa Bay Buccaneers - Over/Under 41.5
Favorite Additional Spots
- Chiefs on the road against the Colts - Implied Team Total 28
- Eagles on the road against the Commanders - Implied Team Total 27
- Chargers at home vs. the Jaguars - Implied Team Total 27.25
- Bengals on the road against the Jets - Implied Team Total 25.5
- Raiders on the road against the Titans - Implied Team Total 23.75
- Saints on the road against the Panthers - Implied Team Total 22
CASH GAMES
Quarterbacks
| Rank | Play | Opponent | Salary |
| 1 | Josh Allen | at Dolphins | $8,200 |
| 2 | Patrick Mahomes II | at Colts | $7,900 |
| 3 | Jalen Hurts | at Commanders | $7,600 |
| 4 | Lamar Jackson | at Patriots | $8,000 |
| 5 | Tua Tagovailoa | vs. Bills | $6,100 |
Josh Allen was the overall QB1 last season and he remains the favorite to end that way again in 2022. Allen ranks second in Expected Points Added per Play (EPA/Play) and fourth in Completion Percentage Over Expected (CPOE) and the Bills rank first in Pass Rate Over Expected (PROE) and third in Early Down Pass Frequency Rate (EDPF). Allen is elite and Buffalo knows it, running their entire offense through him. The Bills at Dolphins contest is tied for the highest Over/Under (52.5) of the week and Buffalo is tied for the highest Implied Team Total (52.5) of the week.
Patrick Mahomes II is right there with Josh Allen competing for the overall QB1 in fantasy. Mahomes ranks first in EPA/Play and second in CPOE and the Chiefs rank second in PROE and first in EDPF. Kansas City has the third-highest Implied Team Total (28) of the week and the matchup against the Colts doesn't scare anyone.