Every week, the first step of your DFS homework should be to examine the opening Vegas odds on all the NFL games for that week. Through some fairly simple algebra, it is easy to derive a spreadsheet that predicts team totals for every game, allowing you to develop a rudimentary game script to help narrow down your weekly decisions. Once the appealing (and unappealing) games have been highlighted, it becomes easier to focus on those games to help build your core of players for that week; the caveat, however, is that the NFL is a dynamic league, and anything is subject to change from Tuesday to Sunday...so keep that in mind as the week progresses and always monitor player injuries, weather conditions, and potential roster moves. Let's take a look.
[Red font indicates Thanksgiving Day games; blue font indicates remaining non-main slate DFS games.]
UPDATED SUNDAY, NOVEMBER 26th @ 8 AM (EST)
| Team | Opponent | Odds | Game Total | Team Total | Passing | Running | Team Defense |
| Dallas | Washington | -11 | 48.5 | 29.75 | ««« | ««« | « |
| Detroit | Green Bay | -7.5 | 47.5 | 27.5 | «« | ««« | |
| Kansas City | Las Vegas | -9.5 | 43.5 | 26.5 | «« | ««« | «« |
| Baltimore | LA Chargers | -3 | 48.5 | 25.75 | « | « | |
| Philadelphia | Buffalo | -3 | 48.5 | 25.75 | « | « | |
| Miami | NY Jets | -10 | 40 | 25 | « | «« | ««« |
| San Francisco | Seattle | -6.5 | 43 | 24.75 | « | « | « |
| Jacksonville | Houston | -1 | 48 | 24.5 | « | « | |
| Indianapolis | Tampa Bay | -2.5 | 45.5 | 24 | « | « | |
| LA Rams | Arizona | -3 | 45 | 24 | « | « | |
| Houston | Jacksonville | 1 | 48 | 23.5 | |||
| Minnesota | Chicago | -3 | 43 | 23 | |||
| Buffalo | Philadelphia | 3 | 48.5 | 22.75 | |||
| LA Chargers | Baltimore | 3 | 48.5 | 22.75 | |||
| New Orleans | Atlanta | -2 | 41.5 | 21.75 | « | ||
| Tampa Bay | Indianapolis | 2.5 | 45.5 | 21.5 | |||
| Arizona | LA Rams | 3 | 45 | 21 | |||
| Chicago | Minnesota | 3 | 43 | 20 | |||
| Tennessee | Carolina | -3.5 | 36.5 | 20 | «« | ||
| Green Bay | Detroit | 7.5 | 47.5 | 20 | Photos provided by Imagn Images
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